Anthracycline-mediated cardiac dysfunction: An endothelial perspective

medRxiv 2026 Preprint Open access

Read full text
Authors: Kasturi Markandran, Tricia Jingwen Ng, Elena Tan, Czaryna Kaye Mendoza Clemente, Rina Miao Qin Wang, Yee Phong Lim, Karan Attal, Kristine Nicole Mendoza Clemente, Hannah Su-Ann Wee, Hammresh S, Christine Cheung, Sik Yin Roger Foo
+1 more Ching Kit Chen
DOI: 10.64898/2026.03.02.26347478
Cited by: 0
References: 70

Abstract

Abstract Background Anthracyclines are central to childhood cancer therapy but predispose patients to cardiotoxicity leading to long-term cardiovascular risk. Endothelial injury and impaired repair contribute to this, yet pediatric data remain limited. Objective To longitudinally assess endothelial injury and repair in childhood cancer patients treated with anthracyclines by quantifying circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs). Methods In a single-centre retrospective cohort, children (

Fields of Study & Subjects

Chemotherapy-induced cardiotoxicity and mitigation Angiogenesis and VEGF in Cancer Cardiac tumors and thrombi

Publication details

Journal / source
medRxiv
Publication date
4 March 2026
Language
EN
Document type
Preprint