Cytotoxic and regulatory CD8 T cells dynamics underlies ICI-myotoxicity outcome

medRxiv 2026 Preprint Open access

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Authors: Runci Wang, Chunyan Xiang, Adrien Procureur, J. Dal Cin, Soon-Min Hong, Boyang Zhang, Xiaolin Lin, Xinyue Lian, Guangcheng Liu, Wu Wei, Xueqin Chen, Xiuying XIAO
+8 more Xiaoxiang Chen, Xiaodong Wang, Michèlle Rosenzwajg, Yves Allenbach, Qiong Fu, Nan Shen, Joe‐Elie Salem, Shuang Ye
DOI: 10.64898/2026.03.03.26347221
Cited by: 0
References: 20

Abstract

Abstract Immune checkpoint inhibitor–induced myotoxicity (ICI-M) comprises myocarditis, myositis, and myasthenia gravis–like syndrome, demanding rapid recognition and therapy. Using immunophenotyping and transcriptomics analysis from blood and muscle, we identified distinct CD38 hi and KIR + CD8 T cells in ICI-M. Abatacept rescued patients and altered the composition and clonality of these cells. Dynamics of CD38 hi and KIR + CD8 T cells effectively supported therapeutic monitoring, offering personalized treatment in life-threatening irAEs.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology Inflammatory Myopathies and Dermatomyositis

Publication details

Journal / source
medRxiv
Publication date
10 March 2026
Language
EN
Document type
Preprint