WITHDRAWN: Beyond Binding Affinity: The Kinetic-Compatibility Hypothesis for Nipah Virus Neutralization: Decoding the Affinity Paradox Across 1,194 Designed Miniproteins

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Authors: Çağlar Bozkurt
Cited by: 0
References: 5

Abstract

Withdrawal Statement The authors have withdrawn their manuscript because of a fundamental error in the identification of the biological target protein. The analysis was originally framed around the mechanical transitions of the Nipah virus Fusion (F) protein; however, the empirical functional data utilized (from the 2025 AdaptyvBio competition) was directed toward the Attachment (G) glycoprotein. While the sequence-level characterization of the binders remains internally consistent, the mechanical analogies used are not applicable to the Attachment (G) protein architecture. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.

Fields of Study & Subjects

Virology and Viral Diseases Monoclonal and Polyclonal Antibodies Research vaccines and immunoinformatics approaches

Publication details

Journal / source
bioRxiv (Cold Spring Harbor Laboratory)
Publication date
11 March 2026
Language
EN
Document type
Preprint