WITHDRAWN: Beyond Binding Affinity: The Kinetic-Compatibility Hypothesis for Nipah Virus Neutralization: Decoding the Affinity Paradox Across 1,194 Designed Miniproteins
Abstract
Withdrawal Statement The authors have withdrawn their manuscript because of a fundamental error in the identification of the biological target protein. The analysis was originally framed around the mechanical transitions of the Nipah virus Fusion (F) protein; however, the empirical functional data utilized (from the 2025 AdaptyvBio competition) was directed toward the Attachment (G) glycoprotein. While the sequence-level characterization of the binders remains internally consistent, the mechanical analogies used are not applicable to the Attachment (G) protein architecture. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Fields of Study & Subjects
Virology and Viral Diseases
Monoclonal and Polyclonal Antibodies Research
vaccines and immunoinformatics approaches
Publication details
- Journal / source
- bioRxiv (Cold Spring Harbor Laboratory)
- Publication date
- 11 March 2026
- Language
- EN
- Document type
- Preprint