Inherited genetic risk factors in young-onset lung cancer

medRxiv 2026 Preprint Open access

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Authors: Myvizhi Esai Selvan, Bonnie E. Gould Rothberg, Abhijit A. Patel, Jian Sang, Amir Horowitz, D Christiani, Robert J. Klein, Zeynep Hulya Gumus
DOI: 10.64898/2026.04.14.26350822
Cited by: 1
References: 84

Abstract

Abstract Introduction Lung cancer is rare before age 45, and its inherited genetic basis remains poorly defined. Methods We performed whole-genome sequencing in 171 predominantly young-onset lung cancer patients and integrated these data with whole-exome sequencing from six major lung cancer consortia, yielding 9,065 patients. After quality control, analyses focused on 6,545 individuals of European ancestry, the largest ancestral group. We compared the prevalence of rare pathogenic and likely pathogenic (P/LP) germline variants between 186 young-onset (age

Fields of Study & Subjects

Lung Cancer Treatments and Mutations BRCA gene mutations in cancer Genomics and Rare Diseases

Publication details

Journal / source
medRxiv
Publisher
openRxiv
Publication date
15 April 2026
Language
EN
Document type
Preprint