Distinct Hippocampal Cellular Pathologies Influence Cognition Across Diagnostic Categories, Also Distinguishing Schizophrenia from Affective Psychoses

Introduction: Total and social cognition deficits independently predict functioning in psychosis, but targeting these in clinical trials are unsuccessful in improving function. The admixture of schizophrenia and affective psychoses cases could be a roadblock if these differ in cellular pathology. Method: H-MRSI), using categorical and transdiagnostic classifications in 80 participants: 22 non-psychotic affective disorder (NP-aff), 25 healthy controls (HC), and 33 with psychosis (Psy), including 20 schizophrenia and 13 affective psychoses (aff-P) cases. Results: NP-aff and HC had similar total cognition (46.64±12.01 vs 41.10±17.88), both superior to Psy (28.34±12.34; p's