Ultrafast venous and sagittal sinus constrictions in the brain driven by abdominal pressure

bioRxiv (Cold Spring Harbor Laboratory) 2026 Preprint Open access

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Authors: Qingguang Zhang, C. Spencer Garborg, Noah Frank, Fatemeh Salehi Shahrbarbaki, Kevin Turner, Patrick J. Drew
DOI: 10.64898/2026.05.02.722426
Cited by: 2

Abstract

Nearly all the blood supplying the cortex exits via the bridging veins (BVs) that drain into the superior sagittal sinus (SSS), making these vessels key chokepoints for cerebral blood flow. Using optical imaging in head-fixed mice, we found that the SSS and BVs exhibit ultrafast contractions (

Fields of Study & Subjects

Cerebrospinal fluid and hydrocephalus Neuroscience of respiration and sleep Barrier Structure and Function Studies

Publication details

Journal / source
bioRxiv (Cold Spring Harbor Laboratory)
Publisher
openRxiv
Publication date
6 May 2026
Language
EN
Document type
Preprint