Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance

bioRxiv (Cold Spring Harbor Laboratory) 2026 Preprint Open access

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Authors: Gianluca C. Kikidis, Alessandra Raio, Leonardo Sportelli, Linda Antonella Antonucci, A. Bertolino, Antonio Rampino, Pierluigi Selvaggi, DR Weinberger, Giulio Pergola
DOI: 10.64898/2026.05.19.726222
Cited by: 1
References: 98

Abstract

Genetic risk for schizophrenia (SCZ) has been linked to cognitive performance before the onset age. We examined how SCZ-related polygenic risk and resilience variants, and their co-expression patterns in the human brain, were associated with cognitive abilities across development in 16,520 non-psychiatric European and African ancestry children and adults. SCZ risk showed significant negative associations with spatial, verbal, and working memory across ancestries (all t5.8, p=0.03) networks. Cross-ancestry correlations (R=0.52, p

Fields of Study & Subjects

Genetic Associations and Epidemiology Schizophrenia research and treatment Functional Brain Connectivity Studies

Publication details

Journal / source
bioRxiv (Cold Spring Harbor Laboratory)
Publisher
openRxiv
Publication date
19 May 2026
Language
EN
Document type
Preprint