Enhancing slow-wave sleep via non-invasive brain stimulation modulates brain-to-blood clearance of Alzheimer’s disease biomarkers

bioRxiv (Cold Spring Harbor Laboratory) 2026 Preprint Open access

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Authors: Julia Ladenbauer, Paula Schuemann, Youannes Rizk, Robert Malinowski, Buse Dikici, Antje Vogelgesang, Agnes Floeel
DOI: 10.64898/2026.06.22.733841
Cited by: 1
References: 38

Abstract

Abstract Sleep disturbances and neurodegeneration form a bidirectional vicious cycle. During slow-wave sleep, glymphatic processes are thought to facilitate the clearance of metabolic waste, including proteins implicated in Alzheimer’s disease (AD). Aging, and more prominently neurodegeneration, is associated with reductions in slow-wave activity (SWA), which may impair these processes. Within SWA, slow oscillations (SO,

Fields of Study & Subjects

Sleep and Wakefulness Research Cerebrospinal fluid and hydrocephalus EEG and Brain-Computer Interfaces

Publication details

Journal / source
bioRxiv (Cold Spring Harbor Laboratory)
Publisher
openRxiv
Publication date
28 June 2026
Document type
Preprint