Electroencephalographic Transient Beta Event Rates in Autism and Related Neurogenetic Conditions

medRxiv 2026 Preprint Open access

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Authors: Gerardo Parra, Klara Szilagyi, Yael Braverman, Devorah Kranz, Elizabeth Martina Bebin, Raphael Bernier, Jonathan A Bernstein, Elizabeth Berry-Kravis, Joseph Buxbaum, Katarzyna Chawarska, Emma E. Condy, Laura Cornelissen
+40 more Géraldine Dawson, Abigail Dickinson, James D Dziura, Charis Eng, Susan Faja, Jennifer H. Foss‐Feig, Jeffrey P. Gavornik, Antonio Y. Hardan, Ellen Hanson, Shafali Jeste, Linnea Joffe‐Nelson, Alexander Kolevzon, Darcy A. Kreuger, Balu Krishnan, Robert Law, David N. Lieberman, Claire MacKay, Julián A. Martínez-Agosto, Adam J. Naples, Charles A. Nelson, Hope Northrup, Ernest Pedapati, Annapurna Poduri, Vineet Punia, Rajsekar R. Rajaraman, David M. Ritter, Celine A. Saulnier, Frederick Shic, Latha Valluripalli Soorya, Catherine A. Sugar, Kyle E. Takach, Audrey Thurm, Sara Jane Webb, Kimberly Wiltrout, Damla Şentürk, Stephanie R. Jones, Michela Fagiolini, James C. McPartland, Mustafa Şahin, April R. Levin
DOI: 10.64898/2026.08.02.26359366
Cited by: 1
References: 48

Abstract

Abstract Transient beta events (TBE) during electroencephalography (EEG) reflect thalamocortical activity, bridging genotype to phenotype and impacting sensory responsivity. Compared to typically developing controls, we found elevated TBE rate in some children with idiopathic Autism Spectrum Disorder (ASD) and a majority of children with Phelan-McDermid Syndrome, Rett Syndrome, and SYNGAP1 -related disorder. TBE rate thus offers promise as a stratification biomarker with divergent and convergent properties across ASD and neurogenetic conditions, respectively.

Fields of Study & Subjects

Autism Spectrum Disorder Research Congenital heart defects research Genetics and Neurodevelopmental Disorders

Publication details

Journal / source
medRxiv
Publication date
3 August 2026
Language
EN
Document type
Preprint