ADVANCING PRECISION MEDICINE: THE ROLE OF PHARMACOGENOMICS IN PERSONALIZED DRUG THERAPY

The study evaluates the perception of pharmacogenomics-based personalized drug therapy among healthcare professionals in Pakistan. We employed a quantitative cross-sectional design to assess a total of 300 participants from four leading cities of Pakistan (Islamabad, Lahore, Karachi, and Peshawar). The study used purposive non-probability sampling, targeting professionals who have experience in pharmacogenomics and personalized medicine. Standardized questionnaires assessing pharmacogenomics knowledge and attitudes toward personalized medicine were used to collect data. Results A significant positive association is observed between knowledge of pharmacogenomics and attitudes of personalized medicine (r = 0.62, p < 0.01). Additionally, there was a positive correlation with years of experience, and educational level positively correlated with participant knowledge on pharmacogenomics, with those receiving more training being more knowledgeable. Direct comparisons of mean scores of these two groups based on their gender showed that males demonstrated greater pharmacogenomics knowledge (t(94.3) = 6.17, p < 0.05) and more favorable attitudes toward personalized medicine (t(74.8) = −7.54, p < 0.05) compared to females (Table 7). R2 results: 0.470, p