Bacteriophage Therapy: a review and the Portuguese landscape

Revista Portuguesa de Doenças Infecciosas (RPDI) 2026 Open access

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Authors: Joana Alves, Ana Cláudia Carvalho, Carlos Capela, Betânia Faria, Rosalina de Santa Cruz Leite, Luciana Meneses, Diana Priscila Pires, Joana Azeredo
DOI: 10.65332/rpdi.v20.140
Cited by: 0
References: 139

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Abstract

This review provides a comprehensive overview of bacteriophage biology and classification, phage–bacteria interactions, and the mechanisms underlying phage-therapy efficacy, including its activity against biofilms and multidrug-resistant pathogens. It further examines phage–antibiotic synergy, resistance dynamics, safety considerations, pharmacokinetic and pharmacodynamic aspects, and the role of phage banks. Finally, the article discusses clinical evidence supporting phage therapy, emerging applications, and the Portuguese experience, highlighting regulatory, logistical, and clinical pathways that support the integration of phage therapy into modern infectious disease management.

Fields of Study & Subjects

Bacteriophages and microbial interactions Photodynamic Therapy Research Studies Virus-based gene therapy research

Publication details

Journal / source
Revista Portuguesa de Doenças Infecciosas (RPDI)
Volume
20
Issue
1
Pages
1–32
Publication date
17 March 2026
Language
EN