ВЗАИМОСВЯЗЬ ИММУНОМЕТАБОЛИЧЕСКИХ МАРКЕРОВ И КЛИНИЧЕСКИХ ПРОЯВЛЕНИЙ ПРИ НЕСЕГМЕНТАРНОМ ВИТИЛИГО: НА ПРИМЕРЕ ПОПУЛЯЦИИ САМАРКАНДСКОЙ ОБЛАСТИ

Relevance. Non-segmental vitiligo is a chronic polyetiological disease whose prevalence is growing throughout the world, especially in regions with high insolation such as Samarkand region. The disease is characterised by a complex immunometabolic pathogenesis that includes the activation of Th1-mediated inflammation, an increase in the levels of CXCL10 and IFN-γ, pronounced oxidative stress and metabolic disorders. The insufficient study of the relationship between immune, metabolic and antioxidant indicators and the clinical manifestations of vitiligo, as well as the regional features of risk factors, determine the high relevance of further research in this area. Aim of the study. To assess the relationship between immunometabolic markers and the clinical manifestations of non-segmental vitiligo (NV) in patients of Samarkand region and to determine the most informative biomarkers of disease activity. Materials and methods. A single-centre cross-sectional study was carried out, including 112 patients with a diagnosis of NV and 40 healthy volunteers. The clinical indices VASI and VIDA, the Fitzpatrick phototype and the duration of the disease were assessed. The laboratory parameters included the levels of IFN-γ, IL-6, TNF-α and the chemokine CXCL10 (ELISA), the subpopulations of CD4+/CD8+/NK cells (flow cytometry), the indicators of oxidative stress (MDA, SOD, GPO), metabolic indices (lipid profile, HOMA-IR) and vitamin D. Statistical analysis included the t-test, Pearson correlation analysis and ROC analysis (p