A Case Report on Huntington’s Disease Presenting with Progressive Motor and Cognitive Decline
Abstract
An uncommon, hereditary, autosomal dominant neurological condition, Huntington’s disease (HD) is marked by increasing motor dysfunction, cognitive loss, and mental symptoms (Stoker et al., 2022). A trinucleotide (CAG) repeat expansion in the HTT gene on chromosome 4 is the cause of the illness (Kumar et al., 2020). Clinical onset usually happens in mid-adulthood, and symptoms steadily get worse over time, eventually resulting in death and severe disability (Ogilvie et al., 2023). One important diagnostic characteristic is a rich family history spanning several generations (Kringlen et al., 2017). Genetic counseling, family screening, and proper symptom treatment all depend on early detection of HD.
Fields of Study & Subjects
Genetic Neurodegenerative Diseases
Hereditary Neurological Disorders
Neurological diseases and metabolism
Publication details
- Journal / source
- INTERNATIONAL JOURNAL OF APPLIED AND CLINICAL RESEARCH
- Volume
- 4
- Issue
- 01
- Pages
- 5–6
- Publication date
- 15 March 2026
- Language
- EN