Diagnostic value of circRNA-UBAP2 and CXCR4 mRNA expression combined with endoscopic ultrasonography in colorectal cancer

Background: To investigate the clinical value of combining the expression of circular RNA ubiquitin associated protein 2 (circRNA-UBAP2) and chemokine receptor 4 (CXCR4) messenger RNA(mRNA) with endoscopic ultrasonography for the diagnosis of colorectal cancer (CRC).Materials and Methods: A retrospective study was conducted.104 patients with CRC and 87 patients with colorectal adenoma who were admitted to the hospital from May 2022 to May 2024 were enrolled in the study.The expression levels of circRNA-UBAP2 and CXCR4 mRNA in samples were detected.The relationship between the expression of circRNA-UBAP2 and CXCR4 mRNA and clinicopathological features of patients with CRC was analyzed, and the diagnostic efficacy of circRNA-UBAP2 and CXCR4 mRNA combined with endoscopic ultrasonography for CRC were evaluated.Results: The expression levels of circRNA-UBAP2 and CXCR4 mRNA in cancer tissues of patients with CRC were higher than those in adjacent tissues (P