Value of quantitative MRI combined with blood CTC in predicting the prognosis of neoadjuvant chemotherapy for breast cancer

Background:To analyze the value of quantitative parameters of magnetic resonance imaging (MRI) combined with circulating tumor cells (CTC) in predicting the prognosis of neoadjuvant chemotherapy (NAC) for breast cancer.Materials and Methods: Ninety-eight breast cancer patients treated with NAC from January 2022 to January 2024 at our institution were collected.Pathological complete remission (pCR) was evaluated 2 weeks after the end of NAC.According to pCR, the patients were divided into pCR group (n=34) and non-pCR group (n=64).The volume transfer constant (Ktrans), extravascular extracellular space volume ratio (Ve), rate constant (Kep), and positive rate of CTC were compared between the two groups before and after treatment.The area under the receiver operating characteristic (ROC) curve (AUC) was used to express the prognostic value.Results: Among the 98 patients, 34 patients achieved pCR, with a rate of 34.69%.After treatment, Ktrans, Kep, and positive rate of CTC were lower than those before treatment (P