Radiotherapy-associated alterations in granulomatous mastitis: Clinicopathological and immunohistochemical predictors of recurrence and differential diagnosis from breast tumors
Abstract
Background: Granulomatous mastitis (GM) often recurs, and its clinical and pathological overlap with breast malignancies is especially problematic in patients with prior radiotherapy.To identify clinical, pathological, and immunohistochemical predictors of GM recurrence and to evaluate diagnostic challenges in the context of post-radiotherapy alterations.Materials and Methods: A retrospective cohort of 206 GM patients was analyzed (58 with recurrence, 148 without).Baseline clinical factors, pathological features, and immunohistochemical markers were compared.An XGBoost algorithm was applied to construct and validate a recurrence risk model.For patients with a history of breast radiotherapy, additional subgroup analysis was performed, incorporating imaging and pathology review to differentiate GM recurrence from tumor relapse.Results: Recurrence was associated with younger age (
Fields of Study & Subjects
Breast Lesions and Carcinomas
Breast Implant and Reconstruction
Digital Radiography and Breast Imaging
Publication details
- Journal / source
- International Journal of Radiation Research
- Publisher
- InkVista Publishing House
- Volume
- 24
- Issue
- 1
- Pages
- 17–24
- Publication date
- 1 January 2026
- Language
- EN