The Effect of Interval Training on Cdk5/P25/Tau Gene Expression in the Hippocampus of Streptozotocin-Induced Alzheimer's Disease Rat

Introduction: Cyclin-dependent kinase 5 (Cdk5) and p25 are involved in the abnormal hyperphosphorylation of tau protein.The aim of this study was to investigate the effects of interval training on the expression of Cdk5, p25, and tau proteins in the hippocampus of streptozotocin Materials and Methods: For this purpose, 30 male .(STZ)-inducedAlzheimer's disease rats Wistar rats (8 weeks old; 200-250 g) were used.The animals were randomly assigned to three equal groups (n = 10 per group): healthy control, Alzheimer's disease control, and Alzheimer's disease training.Alzheimer's disease was induced by intracerebroventricular injection of STZ at a dose of 3 mg/kg.The training group underwent an interval training protocol consisting of 6-12 high-intensity bouts (1 min at 85-90% VO₂max) interspersed with 5 min of low-intensity running at a speed of 10 m/min on a treadmill.Seventy-two hours after the final training session, hippocampal tissue was removed, and the protein expression levels of Results: The expression levels.Cdk5, p25, and tau were determined by Western blot analysis of Cdk5, p25 and tau genes in the hippocampus of the Alzheimer's control group were significantly higher than in the healthy control group.The expression levels of Cdk5, p25 and tau genes in the Alzheimer's training group were significantly lower than in the Alzheimer's Conclusion: Our findings suggest that interval training may help alleviate.control group neurodegeneration associated with Alzheimer's disease through modulation of the Cdk5/p25 pathway and subsequent reduction in tau protein expression.Further research is needed to evaluate its potential as a complementary therapeutic intervention for Alzheimer's disease.