Serum 25-Hydroxy Vitamin D Levels and Disease Severity in Pediatric Atopic Dermatitis: An Inverse Correlation

Atopic Dermatitis (AD) is a common, chronic, relapsing inflammatory skin disease that typically begins during infancy and early childhood with a complex pathophysiology involving immune dysregulation and skin barrier defects. Because of its immunomodulatory qualities, vitamin D is thought to be a major factor in the severity of AD. Research on vitamin D's function in the pathophysiology of AD is conducted worldwide. Regional data from North Africa is scarce. This study aimed to investigate the correlation between serum "25-HydroxyVitamin-D" levels and the clinical severity of AD in children. A cross-sectional study was conducted involving 200 children (aged 1-12 years) with AD at the Diabetes Center in Al Bayda City from September 2024 to August 2025. The severity of the disease was evaluated using the Scoring Atopic Dermatitis (SCORAD) index, and serum "25-HydroxyVitamin-D" levels were measured. Statistical analysis included descriptive statistics, SPSS v26.0, Pearson's correlation, and ANOVA. The average level of vitamin D was 26.67 ± 15.92 ng/ml. Vitamin D levels (