Key aspects of neonatal adaptation in preterm newborns of gestational age 32–36 weeks and 6 days, whose intestines are colonized by Klebsiella pneumoniae with uge, fim and kfu genes

Introduction . Modern molecular and genetic studies refute the previous concept of the sterility of the intrauterine environment: it has been established that the fetal gastrointestinal tract already contains microorganisms, including Klebsiella pneumonia (KP), whose colonization is determined by a complex of perinatal factors (gestational age, type of feeding, stay in the intensive care unit, and antibiotic therapy). The outcome of colonization of the intestines of premature infants — from asymptomatic carriage to full-blown infection — is determined by the state of local mucosal protection, the immunological reactivity of the child, and the virulent properties of Klebsiella pneumoniae . The presence of genetically determined virulence factors in KP (genes fim , kfu , uge ) and their potential impact on the course of the neonatal period justify the relevance of this study. Study Objective . To study the key aspects of neonatal adaptation in premature newborns of gestational age 32–36 weeks and 6 days, whose intestines are colonized by Klebsiella pneumoniae with uge , fim , and kfu genes. Materials and Methods . A survey was conducted on 30 newborns with a gestational age of 32–36 weeks and 6 days, whose intestines were colonized with Klebsiella pneumoniae (KP). Depending on the genovariant of the strains, the children were divided into three groups: Group 1 included premature infants colonized with KP uge (n=6), Group 2 included uge+fim (n=16), and Group 3 included kfu+uge+fim (n=8). A comprehensive assessment of clinical, laboratory, instrumental, and microbiological indicators was conducted in premature infants. Detection of uge, fim, and kfu genes was performed using real-time polymerase chain reaction (PCR). Results . The article presents data on the course of the neonatal period in 32–36 weeks 6 days of GA children with CR with a different set of genes. It was shown that anthropometric data, the Apgar score, in all groups were comparable. Premature infants with kfu+uge+fim genes had the lowest levels of hemoglobin (113.37±14.82 g/l) and hematocrit (33.73±4.56%) on the 10th–14th day of life (p