The Comprehensive Systematic Review of Effectiveness of Salicylic Acid in Chemical Peeling Procedures for Comedonal Acne
Abstract
Background: Comedonal acne is characterized by open and closed comedones and often requires effective keratolytic agents. Salicylic acid (SA), a lipophilic beta-hydroxy acid, is widely used in chemical peels, but comprehensive systematic evidence focusing specifically on comedonal outcomes is limited. Methods: This systematic review analyzed 52 studies, including randomized controlled trials, and comparative cohort studies. The primary outcome was comedone-specific reduction following SA chemical peels. Secondary outcomes included overall acne improvement, safety, tolerability, and comparison with other peeling agents. Results: Six biweekly sessions of 30% SA peels achieved consistent comedone reductions of 88–90% (p
Fields of Study & Subjects
Acne and Rosacea Treatments and Effects
Dermatologic Treatments and Research
melanin and skin pigmentation
Publication details
- Journal / source
- The International Journal of Medical Science and Health Research
- Publisher
- International Medical Journal Corp. Ltd.
- Volume
- 48
- Issue
- 1
- Pages
- 486–539
- Publication date
- 30 May 2026