Association of Preoperative Seizure and Tumor Location with Isocitrate Dehydrogenase 1 Mutation in Intracranial Glioma Patients Underwent Surgery

Background: Gliomas are the most common primary tumors of the central nervous system and form a heterogeneous group of neoplasms with multiple histologic types and malignancy grades, resulting in less diagnostic and prognostic accuracy. Preoperative prediction of IDH1 mutation status from clinical parameters, especially from preoperative seizure and tumor location would enable the clinicians to make optimum management planning. Objective: The purpose of the present study was to evaluate the association of preoperative seizure and tumor location with IDH1 mutation in glioma patients who underwent surgery. Methods & Material: This was a cross-sectional type of analytical study. Cases (n = 110) were selected consecutively as per selection criteria and underwent surgical excision of glioma followed by histopathology and immunohistochemistry for evaluation of IDH1 mutation status. Result: In this study, the study population was 110 with a mean age of 40.75 ± 15.68 years and among them, 66 patients (60.0%) were male. IDH1 mutation was found in 84.0% of diffuse glioma patents. IDH1 mutated cases were younger (39.6 years) than IDH1 wild type cases (47 years). Present study showed a significant association of presence of preoperative seizure with IDH1 mutation (p = 0.021). It also revealed that IDH1 mutation was associated with frontal lobe location of the tumor (p= 0.033). Conclusion: This study has shown a significant association of both preoperative seizure and frontal lobe location with IDH1 mutation in diffuse glioma patients.