How I Treat: Immune dysregulation in Down syndrome
Abstract
Immune dysregulation in Down syndrome (DS) is a highly clinically relevant yet underrecognized feature of this common genetic syndrome. Infection is the leading cause of mortality in DS. This infectious risk likely stems from underlying immunodeficiency compounded by their unique intrinsic anatomy. Furthermore, individuals with DS display a broad range of autoinflammatory and autoimmune diseases, spanning dermatologic, neurologic, and metabolic features, which are often difficult to treat with immunomodulators. Through real clinical vignettes of our patients, we will describe how we treat immune dysregulation in DS.
Fields of Study & Subjects
Immunodeficiency and Autoimmune Disorders
Down syndrome and intellectual disability research
Dermatology and Skin Diseases
Publication details
- Journal / source
- Journal of Human Immunity
- Publisher
- Rockefeller University Press
- Volume
- 2
- Issue
- 4
- Pages
- e20250161–e20250161
- Publication date
- 28 March 2026
- Language
- EN