The mechanism of Buyuan Decoction （补元汤） in improving skeletal muscle atrophy in COPD rats through regulating oxidative stress via the P62/Keap1/Nrf2 signaling pathway

Lishizhen Medicine and Materia Medica Research 2026 Open access

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Authors: Gang Chen, Rongfang Xie, Chunyan Huang, Shiyu CHEN, Yuhao WANG, Shan JIANG, Zhihui LAN
DOI: 10.70976/j.1008-0805.szgygy-2026-01-0104
Cited by: 0

Abstract

目的 探究补元汤调控P62/Keap1/Nrf2信号通路改善大鼠慢性阻塞性肺疾病（COPD）合并骨骼肌萎缩的作用机制。 方法 将18只SD大鼠随机分为三组：对照组，模型组，补元汤组，每组6只。通过香烟烟雾暴露联合脂多糖（LPS）气道滴注构建COPD合并骨骼肌萎缩大鼠模型，造模12周后，连续给药4周后取材；于末次烟熏及末次给药后检测大鼠肺功能：EV、PEF、PIF；ELISA检测血清中氧化应激相关因子水平；试剂盒检测SOD、CAT含量；HE染色观察大鼠肺组织及股四头肌组织病理改变；采用RT-PCR和Western blot测定股四头肌组织中 P62、Keap1、Nrf2的mRNA和蛋白表达；生物力学检测大鼠抓力、体质量、网格时间。 结果 与模型组比较，补元汤组大鼠PEF、PIF、EV（P

Fields of Study & Subjects

Muscle Physiology and Disorders Chronic Obstructive Pulmonary Disease (COPD) Research Genomics phytochemicals and oxidative stress

Publication details

Journal / source
Lishizhen Medicine and Materia Medica Research
Volume
37
Issue
1
Pages
27–32
Publication date
1 January 2026
Language
EN