Effect of acupuncture at bladder nerve segment-related acupoints on urothelial TRPV1 and TRPV4 in rats with overactive bladder

Lishizhen Medicine and Materia Medica Research 2026 Open access

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Authors: Juanrong LINGHU, Rong ZHANG, Caihong Lan, Fujiang DONG, Xianming WU, Yue ZUO, Shuo YANG, Qian Mo
DOI: 10.70976/j.1008-0805.szgygy-2026-0128
Cited by: 0

Abstract

目的 观察针刺对膀胱过度活动（OAB）大鼠尿路上皮中瞬时感受器电位香草酸受体1（TRPV1）和4（TRPV4）的影响，探讨针刺膀胱神经节段相关腧穴治疗OAB的作用机制。 方法 42只雌性SD大鼠随机分为假手术组、模型组、针刺组、针刺+TRPV1激动剂组（针刺+CAP组）、TRPV1拮抗剂组（CPZ组）、针刺+TRPV4激动剂组（针刺+GSK组）、TRPV4拮抗剂组（HC组），每组6只。除假手术组外，其余采用膀胱半梗阻方式制备OAB模型。各组连续干预7 d。检测大鼠膀胱功能、HE染色观察病理损伤程度；q-PCR、WB检测尿路上皮中TRPV1/4的表达。 结果 与假手术组比较：模型组膀胱病理损伤明显；最大膀胱容量、最大逼尿肌收缩压、基础膀胱内压均升高，排尿间隔时间缩短，尿路上皮TRPV1、TRPV4蛋白及mRNA表达量均升高（P

Fields of Study & Subjects

Urinary Bladder and Prostate Research Acupuncture Treatment Research Studies Ion Channels and Receptors

Publication details

Journal / source
Lishizhen Medicine and Materia Medica Research
Volume
37
Issue
1
Pages
175–180
Publication date
1 January 2026
Language
EN