Effect of electroacupuncture on cerbral ischemic injury in rats via regulation of the HIF-1α/BNIP3/Beclin-1 pathway

Lishizhen Medicine and Materia Medica Research 2026 Open access

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Authors: Hong CHE, Yue TANG, Qinghong ZENG, Can LIU, Jie Yu
DOI: 10.70976/j.1008-0805.szgygy-2026-0226
Cited by: 0

Abstract

目的 探讨电针调节HIF-1α/BNIP3/Beclin-1信号通路诱导线粒体自噬，减轻大鼠脑缺血损伤的机制。 方法 50只SD大鼠随机分为假手术、模型、电针、HIF-1α激动剂（DMOG）、电针+DMOG组。线栓法建立MCAO模型，电针组大鼠予“百会”“内关”穴电针治疗，药物组大鼠予DMOG 40mg/kg腹腔注射。Zea-Longa评分评估神经功能，TTC染色测定梗死面积，尼氏染色观察神经元损伤，Western blot检测HIF-1α、BNIP3、Beclin-1及LC3-Ⅱ蛋白表达，电镜观察线粒体自噬。 结果 与假手术组比较，模型组神经功能评分和脑梗死面积显著增加（P

Fields of Study & Subjects

Acupuncture Treatment Research Studies Autophagy in Disease and Therapy Neurological Disease Mechanisms and Treatments

Publication details

Journal / source
Lishizhen Medicine and Materia Medica Research
Volume
37
Issue
2
Pages
372–377
Publication date
1 January 2026
Language
EN