Study on the anti-inflammatory mechanism of medicinal cake-partitioned moxibustion in atherosclerosis treatment based on the ubiquitin-proteasome pathway

Lishizhen Medicine and Materia Medica Research 2026

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Authors: Xuefen WU, Zhou Zhu, Bingxin Wu, Sisi LIN, Xiaofang YANG
DOI: 10.70976/j.1008-0805.szgygy-2026-0327
Cited by: 0

Abstract

目的 探讨隔药饼灸治疗动脉粥样硬化（AS）过程中的抗炎作用及其对泛素-蛋白酶体通路相关分子的影响。 方法 SPF级ApoE-/-雄性小鼠30只复制成AS模型，随机分为模型组、假药饼假灸组、隔药饼灸组。另取同品系SPF级雄性C57BL/6J小鼠10只为正常组，每组分别给予相应干预。HE染色观察主动脉病理状态；ELISA检测血脂、炎症指标含量；免疫荧光和Western blot检测主动脉泛素（Ub）、蛋白酶体20S、NF-κB/p65蛋白共定位及蛋白表达。 结果 小鼠成模后血管内膜一定程度增厚，并形成斑块，血脂和促炎因子含量明显增加，抗炎因子显著减少（P

Fields of Study & Subjects

Acupuncture Treatment Research Studies Atherosclerosis and Cardiovascular Diseases Traditional Chinese Medicine Analysis

Publication details

Journal / source
Lishizhen Medicine and Materia Medica Research
Volume
37
Issue
3
Pages
571–578
Publication date
1 February 2026
Language
EN