Synthesis characterization and Antimicrobial Evaluation of Gelatin Coated Poly (ethylene glycol)-Hydroxyapatite Nanocomposites

Nanotechnology is quick growing field of research having very small dimension particles with multidisciplinary applications in industry, pharmacy, medicine etc. Moreover, the nanomaterials also cover areas such as physics, chemistry, biology, agriculture, material science, including engineering and technology. Nanotechnology has also significantly improved comfort of life due to its multilevel applications in the field of energy production and storage, information technology, medical applications and so on. This study focuses on the synthesis and characterization of a novel nano composite, integrating poly-ethylene glycol (PEG)-grafted gelatin containing hydroxyapatite moieties. The raw material was first compounded and resulting composite were molded into the petridishes. Using Solvent casting process, it is possible to produce scaffolds with mechanical and structural properties close to naturaltrabecular bone. The chemical and thermal properties of synthesized composites and bionanocomposites were investigated by spectral technique. It was observed that the pores in the scaffolds are interconnected and their sizes range from 80 to 400μm. It is known that Hydroxyapatite (HAp) is the most applied calcium phosphate as bone substitutes because of its chemical similarity to the natural calcium phosphate mineral present in biological hard tissues.