Vitamin E supplementation as a metabolic game-changer in diabetes with fatty liver

Background: Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are two prevalent chronic conditions that frequently co-occur in as high as 50–80% of individuals, often complicating management and increasing the risk of cardiovascular disease and liver-related complications. Vitamin E, a potent fat-soluble antioxidant, has emerged as a potential adjunctive therapy for improving liver function and glycemic control in individuals with these coexisting conditions. Aims and Objectives: The aims are to explore the existing evidence on the effects of Vitamin E supplementation on glycemic control in individuals with T2DM and NAFLD, considering its role in oxidative stress modulation, liver health, and overall metabolic management. Materials and Methods: A case–control study was conducted with 100 participants diagnosed with T2DM and NAFLD, divided into two groups: Case group (with Vitamin E supplementation), Vitamin E at a dose of 400 IU once daily for a duration of 6 months and control group (without Vitamin E supplementation). The study assessed various parameters, including fasting blood glucose (FBG), post-prandial blood glucose (PPBG), hemoglobin A1c (HbA1c), liver enzymes (serum glutamic-oxaloacetic transaminase [SGOT], serum glutamic pyruvate transaminase [SGPT]), and the fatty liver index (FLI) before and after 6 months of treatment. Statistical analysis used: Independent samples paired t-test was used to compare the means between two groups. Chi-square test was used to compare the proportions between the groups. P