A prospective study to compare standard and modified hypofractionated adjuvant radiotherapy in patients with carcinoma breast treated with breast conservation surgery

Background: The overall treatment time is reduced in hypofractionated radiotherapy, and a reduction in treatment time helps in the prevention of repopulation of cancer cells. The α/β ratio in tumor tissue of carcinoma breast is almost 4; the dose per fraction in hypofractionation should be more efficacious radiobiologically than the same dose of the conventional regimen. Aims and Objectives: The objectives of this study are to compare locoregional failure, acute toxicities, and distant failure between standard and hypofractionated radiotherapy in carcinoma breast with breast conservation surgery (BCS). Materials and Methods: Patients with BCS received adjuvant radiotherapy in standard hypofractionation 40 Gy in 15# followed by a boost 10Gy in 5# in arm 1 and arm 2, patient received adjuvant radiotherapy with modified hypofractionation 34 Gy in 10# followed by a boost 10Gy in 5#. Results: In arm 1, 60.7% patients had T2 status, 39.3% had T3 status. In arm 2, 46.4% patients had T2 status, 53.6% patients had T3 status. In arm 1, 64.3% patients had N1 status, and in arm 2, 53.6% patients had N1 status. There were increased Grade 2 and Grade 3 radiation dermatitis in arm 2. Conclusion: Early completion of treatment with modified hypofractionated radiotherapy and comparable toxicity, which may be helpful for patients and treatment facilities with a large number of patients.