Direct modification and antimicrobial activity of L-lysyl-L-leucine and its analogues
Abstract
New cationic amphiphiles based on L-lysine and leucine C9--C12 alkyl esters (including optical isomers and structural analogues) were obtained. The influence of certain modifications in them on the antimicrobial activity was evaluated. The lead compound (hydrotrifluoroacetate of L-lysyl-L-leucine decyl ester) showed the highest efficacy with minimum inhibitory concentrations of 0.19 and 0.39 μg ml--1, which is less than that for the control antibiotics vancomycin and ampicillin.
Fields of Study & Subjects
Antimicrobial agents and applications
Antimicrobial Peptides and Activities
Synthesis and Biological Evaluation
Publication details
- Journal / source
- Mendeleev Communications
- Volume
- 36
- Issue
- 2
- Pages
- 148–150
- Publication date
- 1 January 2026
- Language
- RU