Recyclization of exo-methylene bielectrophiles with 2-aminobenzimidazoles as an access to 3-substituted pyrimido[1,2-a]benzimidazol-2-ones
Abstract
Recyclization of 2-(R-amino)benzimidazoles with N-arylitaconimides affords new 1-R-3,4-dihydropyrimido[1,2-a]-benzimidazol-2(1H)-ones bearing acetanilide moiety at position 3. The similar reaction with α-methylene-γ-butyrolactone gives the analogues containing 2-hydroxyethyl substituent. The domino process starts with the aza-Michael addition of the 3-positioned imine atom of benzimidazoles at the activated exo-methylene group of the bielectrophiles.
Fields of Study & Subjects
Synthesis of heterocyclic compounds
Synthesis and Reactions of Organic Compounds
Chemical synthesis and pharmacological studies
Publication details
- Journal / source
- Mendeleev Communications
- Volume
- 36
- Issue
- 2
- Pages
- 188–190
- Publication date
- 1 January 2026
- Language
- RU