Development and examination of self-assembled nanoformulation of biotinylated paclitaxel derivative
Abstract
The attachment of biotin to paclitaxel resulted in a conjugate capable of self-assembling under optimal conditions into spherical nanoparticles with a favorable size distribution and colloidal stability. These nanostructures specifically bind to the model receptor avidin, confirming their potential for both active and passive tumor targeting. Due to their low hemolytic activity, the conjugate nanoparticles can be considered a promising nanoformulation for paclitaxel delivery systems.
Fields of Study & Subjects
Nanoparticle-Based Drug Delivery
Biotin and Related Studies
Nanoplatforms for cancer theranostics
Publication details
- Journal / source
- Mendeleev Communications
- Publisher
- OOO Zhurnal "Mendeleevskie Soobshcheniya"
- Volume
- 36
- Issue
- 3
- Pages
- 298–300
- Publication date
- 1 January 2026
- Language
- RU