Design and synthesis of spiro-linked azacycloalkane--dihydropyrano[4,3-d]pyrimidine compounds

Mendeleev Communications 2026

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Authors: Maxim E. Zhuravlev, Kristina Yu. Komarova, Lyubov Khudiakova, М. В. Чудинов, Alexei Lukin, Dmitry Viktorovich Dar’in
DOI: 10.71267/mencom.7965
Cited by: 0
References: 9

Abstract

New dihydropyrano[4,3-d]pyrimidines bearing 7-positioned spiro-linked azacycloalkane moieties were obtained by the Prins spirocyclization of commercially available N-protected azacycloalkanones followed by the regiospecific condensation with dimethylformamide dimethyl acetal and amidines. The new scaffold thus accessed appears to be a valuable building block for drug development.

Fields of Study & Subjects

Synthesis of heterocyclic compounds Synthesis and Characterization of Heterocyclic Compounds Chemical synthesis and pharmacological studies

Publication details

Journal / source
Mendeleev Communications
Volume
36
Issue
4
Pages
455–456
Publication date
1 January 2026
Language
RU