HMGA1 Activates FGFBP1 Transcription to Enhance Angiogenesis Induction and Tumor Progression via FGF2/FGFR1 Pathway

International Journal of Biological Sciences 2026 Open access

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Authors: Zhe Zhang, Yili Xiong, Mingyang Li, Shengyao Wang, Zhenxing Liu, Guanduo Wang, Huanqing Zhang, Xiaojuan Yang, Gangli Liu, Dongsheng Zhang, Haiwei Wu, Shengyun Huang
DOI: 10.7150/ijbs.109079
Cited by: 2

Abstract

, or FGFR1 also reduced stromal formation and increased tumor necrosis. In human HNSCC, the combined analysis of HMGA1 and FGFBP1 provides a more detailed evaluation of patient prognosis. Our findings highlight a novel paradigm where HMGA1 and FGFBP1 drive tumor progression and angiogenesis, presenting them as potential therapeutic targets for HNSCC.

Fields of Study & Subjects

Fibroblast Growth Factor Research Proteoglycans and glycosaminoglycans research TGF-β signaling in diseases

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
6
Pages
3013–3031
Publication date
26 February 2026
Language
EN