Targeting c-Myc-p300-CARM1 complex induces ferroptosis and reduces CD8 + T cell exhaustion in esophageal squamous cell carcinoma

International Journal of Biological Sciences 2026 Open access

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Authors: Yuhao Wang, Yang Li, Guanzhu Ren, Jin Zhou, W H Chen, Kai Zhang, Xiao Yu, Yin Yin, Ji Cong, Lei Ma, Xinyao Zheng, Yahui Zhao
+1 more Zhihua Liu
DOI: 10.7150/ijbs.114575
Cited by: 1

Abstract

T cell exhaustion, neutrophils, and MDSC. These findings revealed that SGC2085 and MYCi975 could disrupt the transcriptional complex CPC, affect metabolic pathways, and reprogram the immune microenvironment. This study provides a potential therapeutic strategy for ESCC patients.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Immune cells in cancer Cancer Immunotherapy and Biomarkers

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
3
Pages
1266–1282
Publication date
1 January 2026
Language
EN