TIM-4 + skeletal muscle Resident Tissue Macrophages Ferroptosis mediated Rhabdomyolysis in Exertional Heatstroke

International Journal of Biological Sciences 2026 Open access

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Authors: Youyong Tang, Qiyuan An, Keying Zhang, Chenxin Liu, Riqing Wei, Ru Li, Zhiqing Wang, Sixiao He, Fudi Wang, Li Ma, Qiang Ma
DOI: 10.7150/ijbs.114815
Cited by: 1

Abstract

upregulation downstream of HMOX1-driven ferroptosis. Genetic or pharmacological inhibition of HMOX1, or blockade of ferroptosis, reduces TIM-4⁺ smRTM ferroptosis, dampens the JunD-Olfr2-NLRP3-IL-1β axis and significantly attenuates RM in both species. These data identify HMOX1-dependent ferroptosis in TIM-4⁺ smRTMs as a central immunometabolic mechanism of EHS-associated RM and nominate smRTM ferroptosis and the Olfr2-NLRP3 pathway as rational therapeutic targets.

Fields of Study & Subjects

Adipokines Inflammation and Metabolic Diseases GDF15 and Related Biomarkers Ferroptosis and cancer prognosis

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
7
Pages
3432–3450
Publication date
17 March 2026
Language
EN