GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis

International Journal of Biological Sciences 2026 Open access

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Authors: Dongxue Gan, Cheng Yang, Xiangjing Shen, Jingjie Shi, Ronglin Wang, Liaoliao Zhu, Hong Li, Jing Luo, Ting Zhao, Junqiang Li, Yang Song, H.Q. Su
DOI: 10.7150/ijbs.119064
Cited by: 1

Abstract

studies confirmed the inhibitory role of GIPC1 in CRC growth and found that GIPC1-loaded lipid nanoparticles (GIPC1-LNPs) combined with 5-FU treatment had a more significant antitumor effect. In conclusion, this study reveals the GIPC1/TRIM21/TTC7B/mTOR/NF-κB tumor-suppressive axis in CRC and highlights the potential of GIPC1 for early diagnosis and overcoming chemoresistance in CRC patients.

Fields of Study & Subjects

Hippo pathway signaling and YAP/TAZ interferon and immune responses Cancer Mechanisms and Therapy

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
2
Pages
786–801
Publication date
1 January 2026
Language
EN