Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation

International Journal of Biological Sciences 2026 Open access

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Authors: Hong Ding, Wen-Xuan Wang, Qiong-Dan Liang, Chuanfeng Tang, Tang-Di Xu, Zi-An Miao, Bang-Xing Han, Ling-Dong Kong
DOI: 10.7150/ijbs.120307
Cited by: 1

Abstract

mRNA degradation and FAM213A antioxidant effect. This study uncovered that high NLRP6 expression-driven mitochondria-mediated apoptosis could participate in podocyte injury and the suppression of NLRP6 by gastrodin may be an attractive therapeutic approach for podocyte injury.

Fields of Study & Subjects

Renal Diseases and Glomerulopathies Ion Transport and Channel Regulation Genetic and Kidney Cyst Diseases

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
3
Pages
1162–1185
Publication date
1 January 2026
Language
EN