Metformin Sensitizes PTEN-deficient Prostate Cancer to PARP Inhibitors by Rebuilding NADP + Homeostasis

International Journal of Biological Sciences 2026 Open access

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Authors: Xiaodong Hao, Zheng Chao, Hao Peng, Xiangdong Guo, Shuo Zheng, Chunyu Zhang, Hao Ding, Yanan Wang, Zirui Xi, Yuan Gao, Guanyu Qu, Yao Zhu
+4 more Zhiqiang Chen, Peixiang Lan, Le Li, Zhihua Wang
DOI: 10.7150/ijbs.121033
Cited by: 1

Abstract

levels to influence PARPi sensitivity in PTEN-deficient prostate cancer. Additionally, we developed a machine learning model to provide clinicians with personalized predictions for PARPi response.

Fields of Study & Subjects

Metabolism Diabetes and Cancer PARP inhibition in cancer therapy PI3K/AKT/mTOR signaling in cancer

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
3
Pages
1346–1368
Publication date
8 January 2026
Language
EN