Excessive Kynurenine Metabolism Impairs Lysosomal acidification and Triggers mtDNA Release via the AHR/CISH/ATP6V1A Axis in Decidual Macrophages Associated with Unexplained Recurrent Pregnancy Loss

International Journal of Biological Sciences 2026 Open access

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Authors: Guangmin Song, Hongli Li, Man Zhang, Yun Li, Xinyi Tao, Andi Wang, Jianqi Wang, Boris Novakovic, Richard D. Cannon, Richard R.S. Saffery, Hongbo Qi, Hua Zhang
+1 more Xiaobo Zhou
DOI: 10.7150/ijbs.121947
Cited by: 4

Abstract

, excessive administration of KYN in pregnant mice increases the rate of embryo resorption, whereas pharmacological inhibition of AHR partially attenuates cGAS-STING pathway activation in dMφs and ameliorates fetal loss in an abortion-prone mouse model. Collectively, our findings describe a pivotal role for the AHR/CISH/ATP6V1A axis in orchestrating immune dysfunction within the decidua that may contribute to URPL, which sheds new light on the potential pathogenesis of URPL and paves the way for improving pregnancy outcomes.

Fields of Study & Subjects

Reproductive System and Pregnancy Tryptophan and brain disorders Maternal Mental Health During Pregnancy and Postpartum

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
2
Pages
895–919
Publication date
1 January 2026
Language
EN