USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination

International Journal of Biological Sciences 2026 Open access

Read full text
Authors: Jia Cheng, Fang Fang, Zhiheng Li, Jianwei Wang, Linbo Cai, Ling Xu, Yanfang Tao, Juanjuan Yu, Gen Li, Zimu Zhang, Zexi Cui, Yang Yang
+16 more Tiandan Li, Di Wu, Xiaolu Li, Yifang Ding, Zong Zhai, Mengmeng Gu, Xue Li, Xingxing Wu, Pengju Yang, Chunxia Shi, Huike Bai, Xiaodong Wang, Lanlan Han, Lei Shi, Jianqin Li, Jian Ming Pan
DOI: 10.7150/ijbs.122898
Cited by: 1

Abstract

with low toxicity. Mechanistically, USP20 interacts with CTNNB1 and stabilizes the CTNNB1 protein via deubiquitination. Cut&tag analysis indicated that USP20 co-localizes with CTNNB1 on the genome, where they jointly regulate target genes in AML. Collectively, our study identified USP20 as a super-enhancer-regulated oncogene maintaining AML cell survival and proliferation through CTNNB1 stabilization. Pharmacologic targeting of USP20 with AS1517499 presents a promising therapeutic strategy targeting the SE-USP20- CTNNB1 axis.

Fields of Study & Subjects

Acute Myeloid Leukemia Research Ubiquitin and proteasome pathways Blood disorders and treatments

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
5
Pages
2665–2686
Publication date
11 February 2026
Language
EN