Extracellular vesicles derived from irradiated tumor cells foster immunosuppressive macrophages formation to promote esophageal squamous cell carcinoma immune evasion

International Journal of Biological Sciences 2026 Open access

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Authors: Shanshan Jiang, Yechun Pang, Yue Zhou, Jianjiao Ni, Li Chu, Xiao Chu, Jianghong ZHANG, Yan Pan, Yida Li, Ruiting Ye, Hongru Chen, Silai Yu
+4 more Tiantian Guo, Chunlin Shao, Xi Yang, Zhengfei Zhu
DOI: 10.7150/ijbs.123646
Cited by: 2

Abstract

Radiation-induced DYNLL1-AS1 in ESCC EVs drives PD-L1⁺ TAMs immunosuppression via SEC22B/ FOXP1 signaling. Combining DYNLL1-AS1 inhibition with PD-L1 blockade may reverse RT-induced immunosuppression, offering a transformative strategy for ESCC radio-immunotherapy.

Fields of Study & Subjects

Extracellular vesicles in disease Immune cells in cancer Nanoplatforms for cancer theranostics

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
2
Pages
802–822
Publication date
1 January 2026
Language
EN