Loss of UFL1 confers enzalutamide resistance of prostate tumors by regulating METTL16-mediated m6A modification of EEF1A1 mRNA

International Journal of Biological Sciences 2026 Open access

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Authors: Xu Wu, Hui Gao, Qianfeng Zhuang, Feng Li, Xingliang Feng, Naiyuan Shao, Wei Zhang, Yuyang Zhang, Xiansheng Zhang
DOI: 10.7150/ijbs.124214
Cited by: 1

Abstract

. Mechanistically, UFL1 loss decreases METTL16 UFMylation, thereby reducing its ubiquitination level and increasing its protein stability. Additionally, METTL16-mediated m6A modification of EEF1A1 mRNA activates the m6A-IGF2BP1 axis, resulting in increased EEF1A1 protein levels and enhanced resistance to ENZ-induced apoptosis. These findings uncover a novel UFL1-METTL16-EEF1A1 signaling pathway that drives ENZ resistance, suggesting that targeting this cascade may offer a promising therapeutic strategy for overcoming ENZ resistance in prostate cancer.

Fields of Study & Subjects

RNA modifications and cancer Ubiquitin and proteasome pathways Cancer Hypoxia and Metabolism

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
3
Pages
1306–1321
Publication date
1 January 2026
Language
EN