Apoptotic Cancer Cell-Primed Cancer-Associated Fibroblasts Suppress Immunosuppressive Macrophages via WISP-1-Integrin α5β3-STAT1 Signaling in Lung Cancer

International Journal of Biological Sciences 2026 Open access

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Authors: Kyungwon Yang, Kiyoon Kim, Hee Ja Kim, Jeesoo Chae, Ye-Ji Lee, Shinyoung Kim, Young-Ho Ahn, Jihee Lee Kang
DOI: 10.7150/ijbs.124282
Cited by: 1

Abstract

T cells and reduced accumulation of regulatory T cells within the tumor. Notably, these effects were abolished by either depletion of WISP-1 from the CM or pharmacological inhibition of STAT1 following recombinant WISP-1 administration. Collectively, our findings identify the WISP-1-integrin α5β3-STAT1 axis as a novel therapeutic target for TAM reprogramming and tumor suppression in lung cancer.

Fields of Study & Subjects

Immune cells in cancer Phagocytosis and Immune Regulation Cancer Cells and Metastasis

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
2
Pages
995–1015
Publication date
1 January 2026
Language
EN