Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling

International Journal of Biological Sciences 2026 Open access

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Authors: Handi Li, Shuo Zhang, Chen Feng, Fangyan Cheng, Yuanyuan Han, Mengxue Wang, Shuai Zhou, Wenbo Shao, Wenzhong Chen, Jingguo Chen, Kai Liu, Yingze Zhang
+1 more Juan Wang
DOI: 10.7150/ijbs.124507
Cited by: 5

Abstract

. Collectively, our findings identify the Piezo1-Ca²⁺-JAK2/STAT3 axis as a key mediator of osteoblast mechanotransduction under pathological loading and a potential therapeutic target for mechanical overload-associated KOA.

Fields of Study & Subjects

Erythrocyte Function and Pathophysiology Osteoarthritis Treatment and Mechanisms Bone Metabolism and Diseases

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
4
Pages
1834–1851
Publication date
15 January 2026
Language
EN