CXCR4 inhibition alleviates prostatic inflammation and pelvic pain via suppressing Th17 cell differentiation and oxidative stress in EAP mice

International Journal of Biological Sciences 2026 Open access

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Authors: Yongtao Hu, Yi Liu, Jialin Meng, Ruijie Hu, Wenming Ma, Wenlong Xu, Kun Tang, Xianchao Dou, Chaozhao Liang, Li Zhang, Jing Chen
DOI: 10.7150/ijbs.124532
Cited by: 3

Abstract

CXCR4 presents a promising therapeutic target for CP/CPPS. Pharmacological blockade of CXCR4 with AMD3100 inhibits Th17 cell differentiation, consequently mitigating inflammatory infiltration and oxidative tissue injury in CP/CPPS.

Fields of Study & Subjects

Urinary Bladder and Prostate Research Pelvic floor disorders treatments Bladder and Urothelial Cancer Treatments

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
4
Pages
2027–2046
Publication date
22 January 2026
Language
EN