Gut Metabolite Indoleacrylic Acid Suppresses Osteoclast Formation by AHR mediated NF-κB Signaling Pathway

International Journal of Biological Sciences 2026 Open access

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Authors: Jinwu Bai, Gao Si, Ruideng Wang, Shilong Su, Jixing Fan, Xi He, Yang Lv, Shan Gao, Fang Zhou
DOI: 10.7150/ijbs.124766
Cited by: 8

Abstract

, daily IA supplementation protected mice against OVX-induced bone loss, with higher PINP and lower CTX-1 levels. Taken together, these findings identified IA as a promising therapeutic candidate capable of suppressing osteoclastogenesis through an AhR-dependent mechanism, providing mechanistic insight and a potential strategy for the treatment of postmenopausal osteoporosis.

Fields of Study & Subjects

Bone Metabolism and Diseases Bone health and osteoporosis research Gut microbiota and health

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
2
Pages
951–969
Publication date
1 January 2026
Language
EN