The function of TLR2 and the microbiome in macrophage-dependent dissemination of nontuberculous mycobacterial gut infection
Abstract
Background: mutant and wild-type zebrafish larvae in both germ-free (GF) and microbiome-colonized conditions. This study for the first time shows the roles of Toll-like receptor 2 (TLR2) and the microbiome in orchestrating immune responses in NTM gut infection and dissemination. Results: mutant larvae compared to the wild type. Notably, the effect of TLR2 on macrophage motility differs between GF and microbiome-colonized conditions. Conclusions: TLR2 and the microbiome play critical roles in modulating host responses to MAC 101 and Mma20 gut infection. Our findings provide new insights into the coordinated roles of TLR2 signaling and the microbiome in controlling infection of mycobacteria via the gut and underscore the importance of TLR2 in macrophage function during mycobacterial gut infection and dissemination.
Fields of Study & Subjects
Mycobacterium research and diagnosis
Tuberculosis Research and Epidemiology
Gut microbiota and health
Publication details
- Journal / source
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Volume
- 22
- Issue
- 10
- Pages
- 5359–5384
- Publication date
- 18 May 2026
- Language
- EN