Sema3d hi Fibroblasts Promote Acute Kidney Injury Fibrotic Progression Through Confining Endothelial Cell Migration

International Journal of Biological Sciences 2026 Open access

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Authors: Qiuyu Xie, Xiaohong Xin, Weijian Yao, Zehua Li, Yuanyuan Ma, Lei Qu, Yiyi Ma, Chengang Xiang, Suxia Wang, Gang Liu, Ying Chen, Li Yang
DOI: 10.7150/ijbs.124971
Cited by: 1

Abstract

fibroblasts was confirmed by analyzing human scRNA-seq data and through immunofluorescence staining of kidney sections from patients with kidney diseases. This study reveals new target for mitigating renal fibrosis and microvascular loss, suggesting that targeting the Sema3d signaling pathway may provide a novel strategy for preventing AKI fibrotic progression.

Fields of Study & Subjects

Renal and related cancers Single-cell and spatial transcriptomics Hippo pathway signaling and YAP/TAZ

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
3
Pages
1283–1305
Publication date
1 January 2026
Language
EN