Luteolin enhances antitumor immunity of B7-H3-targeted bispecific natural killer cell engagers against non-small cell lung cancer

International Journal of Biological Sciences 2026 Open access

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Authors: Shuo Yang, Zhenfeng Zhang, Xi He, Zilu Ouyang, Shuzhen Tang, Manshan Liang, Zhuowen Chen, Yinghua Liu, Yang Huang, Yeneng Dai, ShengFeng HUANG, Bihui Cao
+3 more Zhe-Sheng Chen, Xian Yu, Qi Zhao
DOI: 10.7150/ijbs.125834
Cited by: 2

Abstract

. A B7-H3-targeted bispecific killer cell engager (BiKE) was constructed, and antibody-dependent cell-mediated cytotoxicity (ADCC) was measured to evaluate its combined effect with luteolin. The B7-H3-targeted BiKE showed superior activity when combined with luteolin compared to either treatment of luteolin or BiKE alone. Our findings not only identify B7-H3 as a promising therapeutic target for NSCLC but also suggest luteolin as a potential anticancer adjuvant. The rationally designed combination strategy presented here may enhance existing treatment paradigms for NSCLC.

Fields of Study & Subjects

Immune Cell Function and Interaction Immune Response and Inflammation Cancer Immunotherapy and Biomarkers

Publication details

Journal / source
International Journal of Biological Sciences
Publisher
Ivyspring International Publisher
Volume
22
Issue
7
Pages
3731–3748
Publication date
25 March 2026
Language
EN